Abstract #2252

Tumor burden assessment in a SB CCA.Mdr2-/- cholangiocarcinoma mouse model with gadoxetate disodium-enhanced MRI at 9.4 T

Qianhui Dou¹, Pinzhu Huang², Jesse Kirkpatrick^3,4, Disha Skelton-Badlani², Gopal Varma¹, Aaron K. Grant¹, Yury Popov², and Leo Lee Tsai¹

¹Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States, ²Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, United States, ³Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Liver, Tumor, preclinical models, cholangiocarcinomaCholangiocarcinoma (CCA) is a primary biliary malignancy with very poor prognosis. Early diagnostic detection and effective targeted therapies remain challenging. A novel hepatic fibrosis/CCA mouse model provides an investigative platform, but in vivo tumor detection/tracking is needed. Here we trial the use of in vivo MRI with gadoxetate disodium to detect CCA tumors and to differentiate infiltrative CCA from fibrosis in these models.

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