Abstract #2253

Differentiation between HCC and ICC using 3D amide proton transfer weighted imaging and diffusion kurtosis imaging

Qihao Xu¹, Ailian Liu^1,2, Tao Lin¹, Dandan Zheng³, Xiaoxiao Zhang³, Lihua Chen¹, Qingwei Song¹, Renwang Pu¹, Ying Zhao¹, and Xue Ren¹

¹Department of Radiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China, ²Engineering Research Center for Artificial Intelligence in Medical Imaging, Dalian, China, ³Clinical & Technical Support, Philips Healthcare, Beijing, China

Synopsis

Keywords: Liver, CEST & MTHepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the two most common primary intrahepatic malignant tumors, and the prognosis and treatment methods are significantly different between them. The purpose of this study was to explore the diagnostic ability of APTw and DKI in distinguishing ICC from HCC. When the APTw values were combined with DKI parameters, the AUC was improved from 0.760 to 0.784 and the sensitivity reached 100%. Our preliminary study showed that APTw combined with the mean diffusivity and kurtosis anisotropy values drived from DKI demonstrated a better performance in the differential diagnosis of HCC and ICC.

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