Abstract #2255

MR-Guided Cryoablation to Upregulate the Immune Response in Osteosarcoma

Dara L Kraitchman^1,2,3, Michele Doucet⁴, Sarah J Powers³, Alainah Bhutta⁵, Emily Kulp⁶, Tina Ehtiati⁷, Cheri Rice¹, Cindy Maranto¹, Kathleen Gabrielson³, Cory Brayton³, and Brian Ladle⁴

¹Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²Center for Image-Guided Animal Therapy, Baltimore, MA, United States, ³Department of Molecular & Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Oncology, Johns Hopkins University, Baltimore, MD, United States, ⁵University of Georgia College of Veterinary Medicine, Athens, GA, United States, ⁶Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁷Siemens Medical Solutions USA, Inc., Baltimore, MD, United States

Synopsis

Keywords: Bone, MR-Guided Interventions, cryoablationOsteosarcoma (OSA) is the most common bone cancer in young adults and dogs and almost invariably lethal when the cancer spreads. MR-guided cryoablation offers the potential to cause direct bone necrosis and palliative pain management and has shown the potential to upregulate the immune response in prostate and breast cancer to prevent or shrink metastatic disease. The current study seeks to determine the immune response of MR-guided cryoablation in spontaneously occurring canine osteosarcoma in comparison to X-ray-guided intratumoral Stimulator of Interferon Gene (STING) immunotherapy as determine by survival time and measurement of inflammatory infilitrates.

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