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Abstract #2263

Comparison of Penalty-based IVIM analysis Methods for Predicting Response to Neoadjuvant Chemotherapy in Osteosarcoma

Esha Baidya Kayal1, Devasenathipathy Kandasamy2, Kedar Khare1, Raju Sharma2, Sameer Bakhshi2, and Amit Mehndiratta1,2
1Indian Institute of Technology Delhi, New Delhi, India, New Delhi, India, 2All India Institute of Medical Sciences, New Delhi, India, New Delhi, India

Synopsis

Keywords: MSK, Cancer, Intravoxel Incoherent motion, Chemotherapy response prediction, Performance comparisonPredictive performance of penalty-based IVIM analysis methodologies BE+TV and BE+HPF for response to Neoadjuvant Chemotherapy have been evaluated using clinical dataset with osteosarcoma in comparison with existing IVIM analysis methods. IVIM datasets before and after chemotherapy were analyzed using 5 IVIM analysis methods – Bi-exponential model and two of its segmented variants and penalty-based BE+TV and BE+HPF methods. Results showed, IVIM parameters estimated by BE+TV and BE+HPF methods produced improved prediction of response to chemotherapy in osteosarcoma than the existing IVIM analysis methods at both the time-points, before and after chemotherapy.

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