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Abstract #2269

DCE-MR Lymphangiography Demonstrates Significantly Different Lymphatic Drainage in Patients with a FOXC2 Gene Mutation Compared to Controls

Michael Mills1, Greta Brezgyte1, Bernard Ho2, Julian Pearce2, Kristiana Gordon1,2, Peter S Mortimer1,2, Pia Ostergaard1, and Franklyn A Howe1
1St George's University of London, London, United Kingdom, 2St George's University Hospitals NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Vessels, Genetic Diseases, lymphaticMRI can investigate lymphatic dysfunction and lymphoedema (a chronic swelling of interstitial fluid), however little quantitative research has been published. Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography (DCE-MRL) allows identification of lymph vessels in both healthy and lymphoedematous limbs, and was used to study the oedematous limbs of patients where the lymphoedema was associated with a mutation of the FOXC2 gene. Signal measured in leg lymphatics of these patients (n=6) peaked significantly earlier than in non-oedematous limbs (n=6) and demonstrated higher peak signals, despite an impaired lymphatic system and therefore an expectation of more sluggish drainage.

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Keywords