Abstract #2278

CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T

Joseph H. C. Lai¹, Jianpan Huang¹, Yang Liu^1,2, Se Weon Park^1,2, Jiadi Xu³, and Kannie W. Y. Chan^1,2,3,4,5

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, Hong Kong, ³Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴City University of Hong Kong Shenzhen Research Institute, Shenzhen, China, ⁵Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, Hong Kong

Synopsis

Keywords: Parkinson's Disease, CEST & MTReveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.

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