Abstract #2279

Multimodality Neuroimaging Biomarkers in Parkinson’s Disease

Xiaomeng Zhang¹, Varsha Mohan¹, Dustin Wooten¹, Bradley A Hooker¹, Yuchuan Zhuang¹, Praveen Honhar², Sophie Holmes^2,3, Mika Naganawa², Mark Dias², Robert Comley¹, Richard E Carson^2,4, Sule Tinaz⁵, David Matuskey^2,3,5, Yanping Luo¹, and Sjoerd J Finnema¹

¹Translational Imaging, Neuroscience, Abbvie, North Chicago, IL, United States, ²PET Center, Yale University, New Haven, CT, United States, ³Department of Psychiatry, Yale University, New Haven, CT, United States, ⁴Department of Biomedical Engineering, Yale University, New Haven, CT, United States, ⁵Department of Neurology, Yale University, New Haven, CT, United States

Synopsis

Keywords: Parkinson's Disease, MultimodalNeuroimaging is widely used in Parkinson's disease patients to improve diagnosis, provide insights into the natural history of disease, and facilitate the development of new treatments. Different MRI sequences and contrasts have been employed to study structure and function, whilst PET have been used to image receptors, transporters, enzymes and metabolism. In this study we evaluate relationships between pathological and functional markers of neurodegeneration using a range of advanced MRI and PET methods, in the same subjects, cross sectionally and over time. To the best of our knowledge this combination of markers has yet to be reported.

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