Abstract #2283

Abnormal intrinsic neural timescale in Parkinson’s disease

Yarui Wei¹, Chunyan Zhang², Yuanyuan Peng², Chen Chen ², Shaoqiang Han², Weijian Wang², Yong Zhang², Hong Lu³, and Jingliang Cheng²

¹Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ²Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

Synopsis

Keywords: Parkinson's Disease, fMRI (resting state)It’s unclear whether abnormal neural information stored and different temporal feature at different stages in Parkinson’s disease (PD). Here, we estimated the intrinsic timescales using the magnitude of the autocorrelation of intrinsic neural signals by resting state functional magnetic resonance imaging data in 74 PD patients, including 44 patients in the early stage and 30 patients in the late stage. Our findings suggest that PD patients exhibit abnormal intrinsic timescales in visual, sensorimotor, and cognitive systems, and at different stages, distinct patterns of intrinsic timescales in cerebral cortex, which might provide new insights for the neural substrate of PD.

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