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Abstract #2284

Effect of levodopa on brain functional network connectivity in Parkinson’s disease patients with MCI.

Karthik R Sreenivasan1, Xiaowei Zhuang1, Jessica Caldwell1, Aaron Ritter2, Dietmar Cordes1, Zoltan Mari1, Natividad Stover3, Talene Yacoubian3, and Virendra Mishra1,4
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Memory & Cognitive Disorders Program Hoag, Pickup Family Neurosciences Institute, Newport Beach, CA, United States, 3Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, United States, 4Department of Radiology, The University of Alabama at Birmingham, Birmingham, AL, United States

Synopsis

Keywords: Parkinson's Disease, Brain ConnectivityMild cognitive impairment in PD patients (PD-MCI) is shown to be a risk factor for the development of dementia over time. However, the distinct factors that contribute to conversion from MCI to dementia are not completely understood. While earlier studies have identified altered functional connectivity (FC) it is still not clear whether PD medication affects brain FC. In the current study, we aim to quantify the impact of medication effect on FC in PD-MCI using resting-state functional MRI. Our findings suggest that altered FC was observed between the groups and with respect to the medication state in the PD-MCI group.

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