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Abstract #2287

Histogram analysis of diffusion kurtosis imaging of deep brain nuclei in Parkinson's disease with different motor subtypes

Jin Wang1, Qiu Bi2, Linyu Chen1, Shan Li3, Hongjiang Zhang2, Changxin Cheng1, Yunzhu Wu4, and Bo Wang2
1Medical school, Kunming University of Science and Technology, Kunming, China, 2Department of MRI, the First People’s Hospital of Yunnan Province, Kunming, China, 3Department of Neurology, the First People’s Hospital of Yunnan Province, Kunming, China, 4MR Scientific Marketing, Siemens Healthineers Ltd., Kunming, China

Synopsis

Keywords: Parkinson's Disease, Gray Matter

Parkinson's disease (PD) has significant clinical heterogeneity. According to its motor symptoms, PD could be divided into two principal clinical subtypes: tremor-dominant (TD) and postural instability and gait disorder (PIGD). Identifying clinical subtypes of PD could serve to better understand the underlying disease mechanisms, predict progression, and guide treatment. In this study, diffusion kurtosis imaging (DKI) combined with histogram analysis were used to evaluate the microstructural changes of the deep brain gray matter nuclei in PD patients. And it demonstrated that DKI histogram analysis was useful to diagnose and discriminate different motor subtypes of PD.

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Keywords