Abstract #2288

Disrupted Brain Structural Network Connection in de novo Parkinson’s Disease with Rapid Eye Movement Sleep Behavior Disorder

Amei Chen¹, Junxiang Huang², Xiaofei Huang¹, Xiaofang Cheng³, Yongzhou Xu ⁴, and Xinhua Wei¹

¹Guangzhou First People's Hospital, Guangzhou, China, ²Guangzhou Women and Children's Medical Center, Guangzhou, China, ³The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China, ⁴Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Parkinson's Disease, White Matter, White matter connectivity, rapid movement sleep behavior disorderTo investigate the changes of white matter structural network connectivity in PD patients with probably rapid movement sleep behavior disorder (PD-pRBD). This study included PD-pRBD (n = 74) and PD with no probably RBD (PD-npRBD)(n = 97) and healthy contral (HC, n=73). The results showed that compared with the PD-npRBD group, the nodal efficiency (Ne) of the right insula and left middle frontal gyrus increased, while the Ne of the left temporal pole decreased. We conclude that changes in the right insula, left temporal pole and left middle frontal gyrus Ne may play key roles in the pathogenesis of PD-RBD.

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