Abstract #2294

Dobutamine-induced Stress Altered Cerebral Blood Flow in Healthy Adults: a 3D Pseudocontinuous Arterial Spin Labeling Study

Pengling Ren¹, Tingting zhang¹, Haijun Niu², Yawen Liu², Linkun Cai², erwei zhao³, Yishi Wang⁴, Yi Zhu⁴, Dong Liu¹, Min Li¹, Wenjuan Liu¹, Penggang Qiao¹, Wei Zheng³, Zhenghan Yang¹, and Zhenchang Wang¹

¹Beijing Friendship Hospital, Capital Medical University, Beijing, China, ²School of Biological Science and Medical Engineering, Beihang University, Beijing, China, ³National Space Science Center, Chinese Academy of Sciences, Beijing, China, ⁴Philips Healthcare, Beijing, China

Synopsis

Keywords: Blood vessels, Arterial spin labelling, Dobutamine StressIt is not fully known whether dobutamine commonly clinically used in echocardiography and short-term treatment of congestive heart failure has effect on brain microcirculatory behavior. In this study, we sought to investigate the effect of dobutamine on cerebral haemodynamics in healthy volunteers. The results showed that dobutamine-induced stress significantly decreased the CBF in the anterior circulation, mainly in frontal lobe. Furthermore, volunteers with high BMI, large BA diameter and low SBP during dobutamine stress test are more likely to have stress-induced decrease of CBF.

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