Abstract #2300

Alterations of cerebrovascular reactivity and morphologies in de novo Parkinson's disease

Hongwei Li¹, Xiali Shao², Bingyi Wang¹, Jian Wang^2,3, Jia Jia⁴, Zhensen Chen^1,5, He Wang^1,5,6, and Lirong Jin⁴

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, ³Department of Radiology, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China, ⁴Department of Neurology, Zhongshan Hospital, Fudan Universit, Shanghai, China, ⁵Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China, ⁶Human Phenome Institute, Fudan University, Shanghai, China

Synopsis

Keywords: Blood vessels, BrainIncreasing evidence showed that vascular changes might be involved in Parkinson's disease. However, the altered markers of neurovascular unit and cerebral vessels that serve as blood flow adaptors, remain unclear in early stage of de novo PD. In this study, we aimed to investigate regional cerebral blood flow (CBF), cerebrovascular reactivity (CVR) and artery morphological changes in de novo PD patients including cognitive impairment (PD-MCI) and normal cognition (PD-NC). Our data revealed that in the patient group, CVR was significantly reduced in left superior occipital gyrus, whose feeding arteries were dilated, but there was no significant change in CBF.

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