Abstract #2302

Correlation of volume transfer constant measured from WEPCAST and DCE-MRI: A pilot study

Dinil Sasi Sankaralayam¹, Wen Shi¹, Zixuan Lin², Anna DuVal³, Kaisha Hazel¹, Katie Ecoff³, Dengrong Jiang², Shiv Saidha³, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Johns Hopkins University, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Blood vessels, Contrast AgentThere is an unmet need of a non-invasive technique to compute the water exchange between vascular and extra-vascular space in the brain since blood brain barrier (BBB) disruption is common in many pathologies and the state of art exogenous contrast agent based method cann’t be applied to all clinical population. So, the current study is aimed at computing a volume transfer constant (Ktrans) from water-extraction-with-phase-contrast-arterial-spin-labelling (WEPCAST) method and to compare it with the global Ktrans from DCE-MRI data. Results of the study finds a good correlation between Ktrans computed from WEPCAST and DCE-MRI data.

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