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Abstract #2307

Hormone-driven CBF and AAT changes across the menstrual cycle

Melissa Emily Wright1, Andrew Crofts1, Saajan Davies1, Michael Germuska1, Jessica J Steventon2, and Kevin Murphy1
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Medicine, Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Blood vessels, Arterial spin labelling

The current study investigated the influence of progesterone and oestrogen on cerebral blood flow (CBF) and arterial arrival time (AAT) across a menstrual cycle and multiple cortical and subcortical regions. 21 healthy female participants were scanned in a Siemens MAGNETOM Prisma 3T scanner and their bloods were taken to measure circulating hormones. Linear models found that while there was no interactive effect with region for either hormone, circulating oestrogen explained a significant portion of CBF value, while progesterone explained a significant portion of AAT value. Recommendations for future research are discussed.

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Keywords