Abstract #2314

Characterizing Quantitative Magnetization Transfer Maps from an MR-Linac in Regions of Progression in Biopsy-Only Glioblastoma

Rachel W Chan¹, Liam SP Lawrence², Hany Soliman³, Mark Ruschin⁴, James Stewart⁴, Aimee Theriault⁴, Chia-Lin Tseng⁵, Sten Myrehaug³, Jay Detsky⁴, Pejman J Maralani⁶, Hanbo Chen⁴, Brandon Tran², Mary Jane Lim-Fat⁷, Sunit Das⁸, Greg J Stanisz^1,2,9, Arjun Sahgal⁴, and Angus Z Lau¹

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Department of Radiation Oncolog, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁶Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁷Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada, ⁸Department of Surgery, St. Michael’s Hospital, Toronto, ON, Canada, ⁹Department of Neurosurgery and Paediatric Neurosurgery, Medical University, Lublin, Poland

Synopsis

Keywords: Tumors, CEST & MT, RadiotherapyIn biopsy-only glioblastoma patients scanned and treated on a 1.5T MR-Linac, this study quantifies the relationship between the quantitative magnetization transfer (qMT) semi-solid fraction and enhancing regions seen on post-contrast T₁-weighted imaging on follow-up MRI scans. Metrics were computed to assess the spatial overlap between low semi-solid fraction regions and enhancing regions. In certain patients, the low semi-solid fraction region at the time of treatment correlated with enhancing region at follow up imaging. Our results suggest reduced semi-solid fraction values precede tumour progression, which could be used for guiding dose adaptation in radiation therapy.

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