Abstract #2316

Functional mapping in gliomas: a comparison between presurgical resting-state fMRI and intraoperative Direct Electrical Stimulation

Manuela Moretto¹, Beatrice Federica Luciani¹, Francesca Saviola¹, Stefano Tambalo¹, Luca Zigiotto^2,3, Donna Gift Cabalo^1,4, Luciano Annicchiarico^2,3, Martina Venturini^2,3, Silvio Sarubbo^2,3, and Jorge Jovicich¹

¹Center for Mind/Brain Sciences (CIMeC), University of Trento, Trento, Italy, ²Department of Neuroscience, Division of Neurosurgery, S.Chiara Hospital, APSS Trento, Trento, Italy, ³Structural and Functional Connectivity Lab, S.Chiara Hospital, APSS Trento, Trento, Italy, ⁴Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Tumors, fMRI (resting state), Brain ConnectivityResting-state functional MRI (rs-fMRI) has been proposed as a non-invasive technique for the presurgical mapping of functional networks, in contrast to intraoperative Direct Electrical Stimulation (DES) mapping. While previous studies have investigated the agreement between a predefined DES atlas and resting-state networks in low-grade glioma patients, here we exploit patient-specific DES points and the ReStNeuMap tool to investigate the agreement between sensorimotor, language and speech-articulation networks in a cohort of high- and low-grade glioma patients. We found a good overlap between ReStNeuMap-derived networks and DES points, while low spatial similarity between networks and functional connectivity maps derived from DES.

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