Abstract #2317

A robust MRSI protocol to investigate glutamatergic mechanisms in glioma

Seyma Alcicek^1,2,3,4, Michael W. Ronellenfitsch^2,3,4,5, Dennis C. Thomas^1,2,3,4, Joachim P. Steinbach^2,3,4,5, Vincent Prinz⁶, Marie-Thérèse Forster⁶, Elke Hattingen^1,2,3,4, Ulrich Pilatus^1,2,3,4, and Katharina J. Wenger^1,2,3,4

¹Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany, ²University Cancer Center Frankfurt (UCT), Frankfurt am Main, Germany, ³Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany, ⁴German Cancer Research Center (DKFZ) Heidelberg, Germany and German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany, ⁵Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany, ⁶Department of Neurosurgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany

Synopsis

Keywords: Tumors, Spectroscopy

Glutamate metabolism plays a significant role in glioma invasion and growth and may lead to glioma-associated epileptic discharges and excitotoxicity. In in vivo MR spectroscopy, the molecular similarity of glutamate and glutamine results in overlapped, hence indistinguishable, spectral peaks and hinders their quantification. Here, we propose the use of J-modulation at optimum echo time for accurate and separate quantification of glutamate and glutamine. To study the reproducibility of this approach, in vivo MRSI sLASER measurement at 120 ms echo time was evaluated in three healthy subjects in two separate sessions, and the findings are reported.

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