Abstract #2319

Correlation of T1- to T2-weighted signal intensity ratio with T1- and T2-relaxation time and IDH mutation status in glioma

Takahiro Sanada¹, Shota Yamamoto^1,2, Mio Sakai³, Toru Umehara^2,4, Hirotaka Sato^1,5, Masato Saito¹, Nobuyuki Mitsui¹, Satoru Hiroshima¹, Ryogo Anei⁶, Yonehiro Kanemura⁷, Mishie Tanino⁸, Katsuyuki Nakanishi³, Haruhiko Kishima², and Manabu Kinoshita^1,9

¹Neurosurgery, Asahikawa Medical University, Asahikawa, Japan, ²Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan, ³Diagnostic Radiology, Osaka International Cancer Institute, Osaka, Japan, ⁴Neurosurgery, Hanwa Memorial Hospital, Osaka, Japan, ⁵Neurosurgery, Japanese Red Cross Kitami Hospital, Kitami, Japan, ⁶Neurosugery, Moriyama Hospital, Asahikawa, Japan, ⁷Biomedical Research and Innovation, Institute for Clinical Research, National Hospital Organization Osaka National Hospital, Osaka, Japan, ⁸Diagnostic Pathology, Asahikawa Medical University, Asahikawa, Japan, ⁹Neurosugery, Osaka International Cancer Institute, Osaka, Japan

Synopsis

Keywords: Tumors, RadiomicsThe current study aimed to test whether the ratio of T1-weighted to T2-weighted signal intensity (rT1/T2) derived from conventional MRI could act as a surrogate relaxation time predictive of IDH mutation status in histologically lower-grade gliomas. The findings showed that rT1/T2 strongly correlates with T1- and T2-relaxation times in histologically LrGGs. The mean value of rT1/T2 was able to discriminate IDHwt and IDHmt tumors in two domestic cohorts, with statistical significance. However, this result was not validated in the original TCIA/TCGA cohort due to the wide variety of imaging characteristics in the cohort.

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