Abstract #2320

DCE-MRI in Distinguishing Solitary Brain Metastasis from Glioblastoma: Evaluation of Multiple Pharmacokinetic Models

Bao Wang¹, Yuan Yao¹, Jingzhen He¹, and Dmytro Pylypenko²

¹Radiology, Qilu Hospital of Shandong University, Jinan, China, ²GE Healthcare, Beijing, China

Synopsis

Keywords: Tumors, DSC & DCE Perfusion

This study aimed to explore performances of parameters derived from DCE-MRI with multiple pharmacokinetic models regarding this differential diagnosis, as well as overall performances of models. Eighty-eight patients with suspected GBM and SBM underwent DCE-MRI in this study. Peritumoral v_p from shutter-speed model achieved the best single-parameter’s performance. Additionally, shutter-speed model achieved the highest overall separating performance. Shutter-speed is the recommended DCE-MRI pharmacokinetic model for differential diagnosis between GBM and SBM.

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