Abstract #2325

Benefit of Vessel Size/Architecture Imaging with DSC-MRI for Differentiation of Tumor Recurrence versus Pseudoprogression in Glioma Patients

Jian Ming Teo^1,2, Jason M Johnson³, Halyna Pokhylevych³, Kinsey Lano³, Ping Hou¹, Xinzeng Wang⁴, and Ho-Ling Liu¹

¹Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, United States, ³Department of Neuroradiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁴GE Healthcare, Houston, TX, United States

Synopsis

Keywords: Tumors, DSC & DCE Perfusion, GliomasVessel Size Imaging was performed on twenty-five glioma patients to obtain voxel-wise relative vessel size index and peak shift maps. This study aimed to investigate if relative vessel size index and difference in peak shift between lesion vs normal appearing white matter voxels will assist in differentiating pseudoprogression vs tumor recurrence for post-treatment gliomas. It was shown that AUC and accuracy increases when incorporating rVSI and difference in peak shift.

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