Abstract #2328

Evaluations of tumor acidosis that monitors early response to radiotherapy in a glioblastoma model using acidoCEST MRI

Michelle Zalles¹, F William Schuler¹, Jorge de la Cerda¹, Alia Khaled¹, Sanhita Sinharay², and Mark D Pagel¹

¹Cancer Systems Imaging, UT MD Anderson Cancer Center, Houston, TX, United States, ²Center for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India

Synopsis

Keywords: Cancer, CEST & MT, pH imagingThe treatment of glioblastoma potentially causes tumor necrosis, which has reduced glycolytic metabolism. AcidoCEST MRI measures tumor acidosis caused by tumor glycolysis. Our study demonstrated that acidoCEST MRI, a molecular imaging method that measures tumor extracellular pH, can detect a decrease in pHe < 7.0 for tumors that resisted radiotherapy or were untreated, and can detect an increase in pHe > 7.0 for tumors that were successfully treated or showed evidence for necrosis.

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