Abstract #2330

MR multitasking-based dynamic imaging forcerebrovascular evaluation (MT-DICE) in brain tumors

Jiayu Xiao¹, Yang Chen¹, Jason Ye², Zhehao Hu¹, Anthony Christodoulou³, Mark Shiroshi¹, Debiao Li³, and Zhaoyang Fan^1,2,4

¹Radiology, Keck School of Medicine of USC, Los Angeles, CA, United States, ²Radiation Oncology, Keck School of Medicine of USC, Los Angeles, CA, United States, ³Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Viterbi School of Engineering, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Tumors, DSC & DCE PerfusionBrain tumors represent a great therapeutic challenge and tend to impact blood brain barrier (BBB) integrity, angiogenesis, and vascularity. Dynamic contrast-enhanced (DCE) MRI is widely used to quantify BBB permeability and dynamic susceptibility contrast MRI (DSC) is used to quantify cerebral perfusion. We incorporated the newly developed MR multitasking-based dynamic imaging for cerebrovascular evaluation (MT-DICE) technique to achieve simultaneous DCE and DSC acquisition with a single-dose injection. MT-DICE could quantify DCE and DSC parameters with good inter-reader agreement in patients with brain tumors. The intratumoral enhanced region showed more severe BBB disruption and higher perfusion than the peritumoral T2-hyperintense regions.

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