Abstract #2334

Quantitative Assessment of Gyrification Patterns and Symmetry of the Fetal Brain based on Routine Fetal 2D MRI

Bossmat Yehuda^1,2, Aviad Rabinowich, MD^1,3,4, Dafi Surani¹, Yair Wexler⁵, Netanell avisdris^1,6, Ori Ben-Zvi¹, Bella Spector^1,6, Leo Joskowicz⁶, Liat Ben-Sira, MD^1,3, Elka Miller, MD⁷, and Dafna Ben Bashat^1,2,4

¹Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ³Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁴Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁵School of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, ⁶School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, ⁷CHEO Medical Imaging, University of Ottawa, Ottawa, ON, Canada

Synopsis

Keywords: Fetal, Neuro, gyrificationCurrent clinical assessment of fetal brain gyrification is performed manually and subjectively. Previous studies that suggested methods for quantitative assessment of fetal brain gyrification were based on 3D reconstruction. In this study we propose an automatic method for quantifying the gyrification from routinely acquired 2D clinical data. We calculate five different gyrification indices for both the right and left hemispheres. We present developmental curves of 134 control fetuses in a wide range of GA (18-37 weeks) and demonstrate differences between control fetuses and fetuses with malformation of cortical development: five with lissencephaly and 13 with polymicrogyria.

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