Abstract #2335

Reduced adiposity in growth-restricted fetuses using quantitative two-point Dixon analysis

Aviad Rabinowich^1,2,3, Netanell Avisdris^1,4, Ayala Zilberman^2,5, Sapir Lazar^2,6, Daphna Link-Sourani¹, Jacky Herzlich^2,7, Bella Specktor-Fadida⁴, Leo Joskowicz⁴, Gustavo Malinger^2,5, Liat Ben Sira^2,6, Liran Hiersch^2,5, and Dafna Ben Bashat^1,2,8

¹Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Department of Radiology, Tel Aviv Soursaky Medical Center, Tel Aviv, Israel, ⁴School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, ⁵Department of Obstetrics and Gynecology, Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁶Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁷Neonatal Intensive Care Unit, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁸Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

Synopsis

Keywords: Fetal, Fetus, Fetal growth restrictionAdipose tissue (AT, i.e., fat) deposition is reduced in undernourished growth-restricted fetuses (FGR) and may correlate with disease severity. Previous studies showed reduced AT using mainly linear sonographic measurements of the subcutaneous fat. We demonstrate the use of a two-point Dixon sequence for whole-body subcutaneous AT. The fat content of 64 fetuses (37 appropriate for gestation age [AGA], 18 FGR, and 9 small for gestational age) was measured using three adiposity parameters. We demonstrated third-trimester AT accretion in AGA fetuses and reduced AT in FGR. This study is the first to demonstrate whole-fetus subcutaneous AT changes in FGR.

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