Abstract #2343

Associations between Maternal Depression during Pregnancy and Neonatal Brain Resting-State Functional Connectivity

Xiaoxu Na¹, Aline Andres^2,3,4, Charles M. Glasier¹, Jayne Bellando², Haitao Chen^5,6,7, Wei Gao^5,6, and Xiawei Ou^1,2,3,4

¹Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, ²Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States, ³Arkansas Children’s Nutrition Center, Little Rock, AR, United States, ⁴Arkansas Children’s Research Institute, Little Rock, AR, United States, ⁵Biomedical Sciences and Imaging, Cedars Sinai Medical Center, Los Angeles, CA, United States, ⁶Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, ⁷Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Neonatal, fMRI (resting state)This study reports associations between maternal depression symptoms during pregnancy and neonatal brain functional connectivity. The mothers self-rated their depression symptoms during pregnancy using Beck Depression Inventory-II, and their newborns underwent a brain MRI examination including structural 3D T1-weighted images and resting-state fMRI for functional connectivity measurements. Most participants scored in the minimal range for depressive symptoms. Significant negative associations between maternal depression symptoms at ~36 weeks of pregnancy and newborn functional connectivity were observed in multiple brain regions/networks, indicating a negative influence of antenatal depression symptoms on neonatal brain functional development even in women with low symptoms of depression.

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