Keywords: Neonatal, Multimodal, postmortem, brain development
The core lesion of SIDS is a set of medullar nuclei with abnormalities correlated with sudden infant death syndrome (SIDS). We performed ex vivo whole brain and brainstem MRI, optical coherence tomography and histology at an unprecedented spatial resolution on a postmortem infant brain to investigate the structural properties of the caudal medulla. In our image processing pipeline, we register all image modalities into the same coordinate system along with a rich set of segmentation labels. Such multimodal construction helps us validate imaging findings at various resolution levels and will serve as prior information in automated segmentation solutions.
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