Abstract #2346
Ultra-high-field 7T Neonatal Proton MRS and Metabolite Relaxation Times
Enrico De Vita1,2,3, Maria Yanez-Lopez4, Anthony N Price2,5, Philippa Bridgen3,6, Shaihan Malik2,3, Megan Quirke2,6,7, Raphael Tomi-Tricot3,7,8, Mary A Rutherford2, Joseph V Hajnal2,3,7, and Tomoki Arichi2,6,9
1MR Physics group, Radiology Department, Great Ormond Street Hospital, London, United Kingdom, 2Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 3London Collaborative Ultra high field System (LoCUS), King’s College London, London, United Kingdom, 4MR Physics Group, Department of Medical Physics and Clinical Engineering, Swansea Bay University Health Board, Swansea, United Kingdom, 5MR Physics, Guys and St Thomas’ NHS Foundation Trust, London, United Kingdom, 6Guys and St Thomas’ NHS Foundation Trust, London, United Kingdom, 7Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 8MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 9MRC Centre for Neurodevelopmental Disorders, King’s College London, London, United Kingdom
Synopsis
Keywords: Neonatal, Spectroscopy, 7T, ultra-high fieldWe present 1H-MRS results from a pilot cohort of newborn infants, acquired on a 7T system. Whilst a customised approach is required for patient preparation and sequence calibrations, our preliminary data points to highly improved sensitivity and data quality at ultra-high field compared to typical spectra from adults at the same field or newborn infants at lower field strengths. We also report initial estimates of T1 and T2 for the main metabolites in the neonatal brain at 7T.
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