Abstract #2348

Cerebral perfusion in neonates with severe congenital heart disease

Alexandra De Silvestro^1,2,3, Giancarlo Natalucci⁴, Maria Feldmann^3,5, Cornelia Hagmann^3,6, Thi Dao Nguyen⁴, Seline Coraj⁴, Beatrice Latal^3,5, Walter Knirsch^1,3, and Ruth Tuura^2,3

¹Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland, ²Center for MR-Research, University Children's Hospital Zurich, Zurich, Switzerland, ³Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland, ⁴Department of Neonatology, University Hospital Zurich, Zurich, Switzerland, ⁵Child Development Center, University Children's Hospital Zurich, Zurich, Switzerland, ⁶Department of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland

Synopsis

Keywords: Neonatal, Arterial spin labellingWe aimed to compare cerebral perfusion in neonates with severe congenital heart disease (CHD) and healthy controls using arterial spin labeling magnetic resonance imaging. Sixty-seven scans of CHD patients and 23 scans of controls were analyzed (postmenstrual age at scan 41.6±1.8 and 41.9±2.1 weeks, respectively). As in healthy neonates, cerebral perfusion in CHD patients increased with age. Whereas age-adjusted whole brain perfusion was similar to controls, redistribution of regional perfusion was detected in CHD patients. Furthermore, the presence of a systemic-to-pulmonary shunt was associated with cerebral hypoperfusion. Effects of cerebral perfusion alterations on neurodevelopment need to be further assessed.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.