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Abstract #2349

Distance-dependent changes in functional connectivity in neonatal brain

Yihan Wu1, Ruolin Li1, Yifan Shuai1, Zhiyong Zhao1, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Neonatal, fMRI (resting state)The present study aimed to explore functional connectivity changes with anatomical distance in neonatal brain by using the second dHCP resting-state fMRI dataset. We calculated distance-dependent functional connectivity density (FCD) maps to test for the effect of age, preterm-birth, and gender. Results found that the FCD in neonatal brains showed distance-dependent changes with PMA, in which the short- and long-range FCD changes were associated with maternal environment and postnatal experience, respectively. Moreover, the preterm- and term-born infants showed different patterns in short- and long-range FCD. These findings suggested distance-dependent changes in functional connectivity in neonatal brain during early development.

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