Abstract #2383

Double-echo phase-incrementing SSel-MQC (pi-SSelMQC) in biomarker imaging with full signal recovery and excellent lipid and water suppression

Qiuhong He¹, Hong Yuan^2,3, and Yen-Yu Ian Shih^2,4,5

¹The School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁴Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁵Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Pulse Sequence Design, SpectroscopyA double-echo pi-SSelMQC method was developed to recover 100% biomarker signals, as compared to spin-echo pulse sequences, with excellent water and lipid suppression. Signals from both ZQ→DQ and DQ→ZQ coherence transfer pathways were detected. By synchronization of phase-encoding steps and RF phase increments of either MQ-preparation or MQ-transfer pulse, the biomarker images from different MQ-pathways were resolved and shifted away from residual lipid and water signals. Full lactate and polyunsaturated fatty acids (PUFA) signals were recovered in pi-SSelMQC imaging using yogurt phantoms, vegetable oil, and murine 344SQ lung tumors grown subcutaneously on the right thigh of syngeneic 129X1/SvJ male mice.

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