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Abstract #2414

Associated high-order resting-state functional connectivity network for diagnosis of schizophrenia

Dafa Shi1, Haoran Zhang1, Guangsong Wang1, and Ke Ren1
1Department of Radiology, Xiang’an Hospital of Xiamen Uneversity,School of Medicine, Xiamen University, Xiamen, China

Synopsis

Keywords: Data Analysis, Brain Connectivity, high-order functional connectivitySchizophrenia (SZ) is one of the most prevalent mental disorders; however, its accurate diagnosis is difficult in clinical practice. Currently, the underlying mechanism of SZ remains poorly understood. The associated higher-order functional connectivity (HOFC) which constructed based on the conventional FC is promising for understanding pathological changes of brain connectome. In our study,we found the model constructed with associated HOFC outperformed the model constructed with conventional FC. SZ-related brain regions were widely distributed in frontal, parietal, insula, occipital, subcortical, and limbic lobes, which are the core brain areas of the subcortical, fronto-parietal, sensorimotor, limbic, and default mode networks.

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