Abstract #2433

Magnetic Resonance Imaging of the Liver Microenvironment to Assess Hepatocellular Carcinoma Growth and Characteristics in Rat

Yeon Ji Chae¹, Hwon Heo¹, Chul-Woong Woo², Sang-Tae Kim², Do-Wan Lee³, Monica Young Choi², Yoonseok Choi⁴, and Dong-Cheol Woo^1,2

¹Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ³Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁴Medical Research Institute, Gangneung Asan Hospital, Gangneung-si, Gangwon-do, Korea, Republic of

Synopsis

Keywords: Liver, Tumor, Magnetic resonance imaging, Liver microenvironment, Nonalcoholic steatohepatitis, Hepatocellular carcinomaIn this study, a syngeneic orthotopic hepatocellular carcinoma (HCC) rat model with nonalcoholic steatohepatitis (NASH) was established to elucidate the role of the liver microenvironment using MRI. Our findings demonstrated that the HCC growth and progression were accelerated by the disease severity of NASH in the syngeneic orthotopic HCC rat model. This suggests that the liver microenvironment is important for HCC promotion.

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