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Abstract #2443

On Intra-Voxel Dephasing in Liver Diffusion-Weighted Imaging

Johannes Raspe1, Sean McTavish1, Kilian Weiss2, Johannes M. Peeters3, Dimitrios C. Karampinos1, and Anh T. Van1
1Department of Diagnostic and Interventional Radiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 2Philips GmbH Market DACH, Hamburg, Germany, 3Philips Healthcare, Eindhoven, Netherlands

Synopsis

Keywords: Liver, Diffusion/other diffusion imaging techniquesMotion is a major source of artifacts in liver diffusion-weighted (DW) imaging leading to severe signal loss. Physical information about motion is encoded in the phase of DW images based on a pulsed gradient spin-echo (PGSE) sequence. The present work proposes a methodology to estimate a phase-predicted attenuation (PPA) which correlates with the magnitude variation of DW images in motion-controlled phantom experiments and in vivo measurements. These phase-based predictions allow to isolate motion-related magnitude attenuation for further investigation of undesired signal loss effects and offer potential for refining algorithms to reduce magnitude loss in DW imaging of the liver.

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Keywords