Abstract #2453

Associations between Weight Change, Knee Subcutaneous Fat and Cartilage Thickness: 4-Year Data from the OAI

Gabby B Joseph¹, Melia Takakusagi¹, Gino Arcilla¹, John Lynch², Valentina Pedoia¹, Sharmila Majumdar¹, Nancy E. Lane³, Michael C Nevitt², Charles E McCulloch², and Thomas M. Link¹

¹Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²Department of Epidemiology and Biostatistics, UCSF, San Francisco, CA, United States, ³Department of Rheumatology, UC Davis, Davis, CA, United States

Synopsis

Keywords: Osteoarthritis, Cartilage

This study assessed the relationship between 4-year changes in: (1) body weight and outcomes of joint-adjacent subcutaneous fat (SCF) and cartilage thickness, and (2) joint-adjacent SCF and knee cartilage thickness. A total of 399 individuals from the Osteoarthritis Initiative with >10% weight gain and >-10% weight loss over 4 years were compared with controls with less than 3% weight change. Weight gain and loss were associated with increases, and decreases, respectively in joint-adjacent SCF. Increases in SCF adjacent to the medial femur were associated with decreases in average cartilage thickness and in several medial and lateral locations in the knee.

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