Abstract #2459

Enabling Early Detection of Knee Osteoarthritis Using Diffusion-Relaxation Correlation Spectrum Imaging

Peng Luo¹, Wentao Hu², Yongming Dai², and Guanwu Li¹

¹Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, ²Central Research Institue, United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Cartilage, Diffusion/other diffusion imaging techniquesEarly OA is subclinical for anatomic change of cartilage, making it difficult for conventional MRI detection. This study is aimed to apply diffusion-relaxation correlation spectrum imaging (DR-CSI) to knee early-stage OA detection. DR-CSI compartment volume fractions V_A, V_B and V_C had correlation with the modified Whole-Organ MR Imaging Scores (WORMS). V_C had better ability than V_A, V_B, V_D, T2 and ADC to discriminate early OA patients from healthy controls. The results illustrated that DR-CSI compartment volume fractions may be sensitive indicators for detecting early-stage degeneration in knee articular cartilage.

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