Abstract #2461

Water content and T2 changes in ex vivo bovine knee cartilage under compressive strain

Andrew C Yung¹, Emily Sullivan^2,3, Jessica C Küpper^2,4, Kirsten Bale¹, Piotr Kozlowski¹, and David Wilson^2,4

¹UBC MRI Research Centre, Radiology, University of British Columbia, Vancouver, BC, Canada, ²Centre for Hip Health and Mobility, Vancouver, BC, Canada, ³School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ⁴Orthopaedics, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Cartilage, Osteoarthritis, StrainWe present a novel approach to cartilage multi-echo data where T2 reflects focal changes in strain along the cartilage depth, and the signal amplitude reflects a measure of water content which presents a simpler pattern of change that reflects strain. Ex vivo bovine knee samples were scanned at 9.4T while under load, with high resolution along the cartilage depth to allow direct measurement of strain. Changes in water content were found to be more spatially uniform than the complex depth dependence shown by T2, and showed a high degree of correlation to whole-cartilage averages of bulk strain.

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