Abstract #2475

Impact of resting physiology on the repeatability of phase contrast MRI measures of cerebral blood flow

Hannah R Johnson^1,2, Rachael C Stickland², Kristina M Zvolanek^1,2, Yufen Chen³, and Molly G Bright^1,2

¹Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, United States, Evanston, IL, United States, ²Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ³Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

Synopsis

Keywords: Blood vessels, Velocity & FlowInterpretation of clinically significant changes in total cerebral blood flow (CBF) can be confounded by normal variability in flow measures. We assessed the effects of resting end-tidal CO₂ (PETCO₂) on inter-session variability in total CBF as measured with phase contrast MRI. Participants were scanned twice, 1-3 weeks apart, with PETCO₂ clamped at resting physiology. Clamping PETCO₂ at participants’ resting respiratory physiology does not notably improve inter-session variability in flow, which was found to be consistent with previously reported values. Furthermore, inter-session changes in resting PETCO₂ did not help to explain noted variability in total CBF.

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