Abstract #2477

Increased pulsatility is associated with higher blood flow in the cerebral microvasculature as assessed with 7T MRI

Elles P. Elschot^1,2, Marieke van den Kerkhof^1,2, Merel M. van der Thiel^1,2,3, Robert J. van Oostenbrugge^2,4,5, Abraham A. Kroon^5,6, Walter H. Backes^1,2,5, and Jacobus F. A. Jansen^1,2,7

¹Radiology & Nuclear Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, ²School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Psychiatry & Neuropsychology, Maastricht University Medical Center +, Maastricht, Netherlands, ⁴Neurology, Maastricht University Medical Center +, Maastricht, Netherlands, ⁵School for Cardiovascular Diseases, Maastricht University, Maastricht, Netherlands, ⁶Internal Medicine, Maastricht University Medical Center +, Maastricht, Netherlands, ⁷Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

Keywords: Blood vessels, HypertensionWe studied blood flow pulsatility and perfusion in the cerebral microvasculature to increase the understanding of the pathophysiological processes in hypertension. By exploiting the possibilities of ultra-high-field strength (7T), utilizing phase contrast MRI and spin-echo dynamic susceptibility MRI, we focused specifically on the microvasculature. We found that a higher blood flow pulsatility in the lenticulostriate arteries is correlated with higher cerebral blood flow. Furthermore, hypertension status seems to have an effect on varying pulsatility, which seems to be counteracted by medication usage.

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