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Abstract #2480

Pulsatility in the circle of Willis increases with age

Henning U. Voss1,2 and Qolamreza R. Razlighi2
1Cornell University, Ithaca, NY, United States, 2Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Blood vessels, Velocity & Flow, Pulsatility, Pulse wavesAs we get older, the elasticity of our blood vessels decreases significantly, which can lead to a diminished absorption of blood pressure pulsations, potentially causing damage including hemorrhagic stroke and microbleeds. We studied pulsatility in the circle of Willis, which has been hypothesized to be a pressure absorber, by the method of MRI hypersampling by analytic phase projection (APP). A significant correlation of pulsatility in the circle of Willis with age was found. This finding is interpreted as an ageing-related increase in pulsatile flow relative to the steady flow component of overall cerebral blood flow.

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