Abstract #2485

Cerebrovascular reactivity differences in the anterior and posterior brain circulations in Healthy individuals

Harrison T. Levine^1,2, Julien Poublanc², Ece Su Sayin^1,2, James Duffin^1,3, Olivia Sobczyk^2,3, Joseph A Fisher^1,3, and David Mikulis²

¹Department of Physiology, University of Toronto, Toronto, ON, Canada, ²Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, ON, Canada, ³Department of Anaesthesiology and Pain Management, University Health Network, Toronto, ON, Canada

Synopsis

Keywords: Blood vessels, fMRI (task based), Cerebrovascular Reactivity

There is no consensus regarding the differences in Cerebrovascular Reactivity (CVR) magnitude differences between anterior and posterior circulations in healthy individuals. Forty-four healthy individuals underwent BOLD fMRI using a standardized blood vascular stress test achieved with sequential gas delivery. These results showed that cerebrovascular magnitude and speed of response tau) were stronger and faster in the posterior circulation compared to anterior circulation tissues. Therefore, the knowledge that there are significant regional differences in CVR is critical for investigating the regional impact of cerebrovascular pathologies.

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