Abstract #2491

Amide proton transfer-weighted MRI of brain tumors with fluid & solid compartment corrections using background magnetization transfer effects

Osamu Togao¹, Jochen Keupp², Koji Yamashita³, Kazufumi Kikuchi⁴, Tatsuhiro Wada⁵, and Kousei Ishigami⁴

¹Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Philips Research, Hamburg, Germany, ³Department of Radiology Informatics and Network, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁴Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁵Division of Radiology, Department of Medical Technology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Synopsis

Keywords: Tumors, CEST & MTWe propose a simple and efficient metric for APT-weighted MRI, which suppresses fluid signals and enhances signals form solid components based on the spectral shape of the background MT ratio. No extra acquisition or mathematical fitting is needed because the metric can be computed from the minimum Z-spectral data required for standard APT-weighted MRI. This post-processing normalizing for background MT effects may facilitate the quantitative evaluation of the APT-weighted signal of the active solid component in brain tumors.

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