Abstract #2498

Histogram analysis of APT Combined with DTI and DSC MRI for Predicting IDH Mutation and MGMT promotor methylation Status in Glioma

Lan Zhang¹, Xinli Zhang¹, Xiaona Fu¹, Yuxi Jia¹, Xiaoming Liu¹, Lan Cheng¹, Zhengwu Tan¹, Xudong Li², Zhengyin Cheng³, Xiaochuan Dong⁴, Peng Sun⁵, Xiaoxiao Zhang⁵, Xiaobin Jiang², Chuansheng Zheng¹, Xuan Wang², and Jing Wang¹

¹Department of Radiology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China., Wuhan, China, ²Department of Neurosurgery, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China., Wuhan, China, ³People's Hospital of Dongxihu District, Wuhan, Hubei, China., Wuhan, China, ⁴Department of Pathology, Union hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China., Wuhan, China, ⁵Clinical & Technical Solutions, Philips Healthcare, Beijing 100600, China., Wuhan, China

Synopsis

Keywords: Tumors, Multi-ContrastIn this study, the diagnostic performance of histogram features of APT, DTI and DSC in predicting IDH mutation and MGMT promoter methylation status of gliomas was compared. Secondly, the histogram parameters from the signal-time intensity curve of DSC significantly improved the predictive performance of DSC model. Most importantly, the combined logistic regression model combined with APT, DTI and DSC can evaluate the tumor nature of glioma more comprehensively and obtain better diagnostic performance, which is expected to become an imaging molecular marker for the prediction of glioma genotyping in the future.

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