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Abstract #2501

A Novel Biomimetic Nanodrug with High Reactive Oxygen Species Production for Precision Combination Therapy of Glioblastoma

Haiyan Gao1 and Meiyun Wang1,2
1Henan provincial People’s Hospital, Zhengzhou, China, 2Laboratory of Brain Science and Brain-Like Intelligence Technology, Institute for Integrated Medical Science and Engineering, Henan Academy of Sciences, Zhengzhou, China

Synopsis

Keywords: Tumors, BrainThis project intends to innovatively design and synthesize novel radiotherapy sensitization and enhanced CDT dual-effect sensitization nanodrugs, further wrap them with engineered red blood cell membrane vesicles, and construct a high-performance biomimetic nanomedicine synergistic treatment system with high targeting, high specificity and high yield of reactive oxygen species, in order to achieve the specificity and high efficiency accumulation of nanomedicines in the GBM, while reducing toxicity to normal tissues. Magnetic resonance and other imaging methods are used to guide the efficient treatment of drugs and monitor the effect of tumor ablation.

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