Abstract #2502

Indirect detection of deuterated glucose brain metabolism at 3 Tesla: preliminary findings in volunteers and patients with gliomas

Adam W Autry¹, Marisa LaFontaine¹, Javier Villanueva-Meyer¹, Susan M Chang², Henk M de Feyter³, and Yan Li¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, ³Department of Radiology and Biomedical Imaging, Magnetic Resonance Research Center, Yale University, New Haven, CT, United States

Synopsis

Keywords: Tumors, Brain, deuterated glucoseThis study aimed to perform indirect detection of deuterated glucose metabolism at 3 Tesla in healthy subjects and patients with brain tumors using time-series data acquired from atlas-based single-voxel spectroscopy and whole-brain 3D magnetic resonance spectroscopic imaging (MRSI). Following ²H-glucose consumption, subjects generally displayed reduced levels of glutamate in the anterior cingulate cortex (ACC) and midline gray matter, while patient T2 lesions did not appear to show the same trend. These preliminary data demonstrate the ability to detect deuterated glucose metabolism at 3 Tesla.

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