Keywords: Tumors, Cell Tracking & Reporter Genes, immune therapyIn order to track immune cells loaded with 19F compound, a nanoformulation based on iron-doped perfluoro-15-crown-5-ether, called Fe-PFCE was developed for Fluorine-19 MRI. It’s relaxation time was characterized with a custom designed 8 channel Fluorine transmit/receive head coil on clinical 3Tesla MR scanner. Its relaxation time (T1/T2) was 39ms/7ms as comparing to 894ms/196ms nanoformulation based on original (undoped) perfluoro-15-crown-5-ether, called “PFCE”. The SNR/19F-concentration ratio of 1ml Fe-PFCE nanoformulation measured by bSSFP was found to be 53% stronger than that of PFCE. A good signal profile was yielded within the coil receiving field.
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