Keywords: Tumors, Brain
Many non-neoplastic pediatric neurological diseases could often mimic brain tumors in conventional neuroimaging. Amide proton transfer-weighted (APTw) imaging adds important value to standard MR imaging sequences in brain tumor diagnosis. The high APT signal of neoplastic lesions seems to be related to the high cellularity of brain tumors and to overexpression of many proteins compared to normal brain tissue. We demonstrate that non-neoplastic lesions are characterized by APT values significantly lower than low grade gliomas (LGGs). APTw imaging may lead to an increased accuracy in differentiating LGGs from non-neoplastic lesions in pediatric patients.
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