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Abstract #2506

Amide Proton Transfer (APT) Imaging in pediatric low grade glioma versus non neoplastic intracranial lesion

Costanza Parodi1, Antonia Ramaglia1, Mariasavina Severino1, Domenico Tortora1, Antonio Verrico1, Claudia Milanaccio1, Maria Luisa Garré1, and Andrea Rossi1
1IRCCS Istituto Giannina Gaslini, Genova, Italy, Genova, Italy

Synopsis

Keywords: Tumors, Brain

Many non-neoplastic pediatric neurological diseases could often mimic brain tumors in conventional neuroimaging. Amide proton transfer-weighted (APTw) imaging adds important value to standard MR imaging sequences in brain tumor diagnosis. The high APT signal of neoplastic lesions seems to be related to the high cellularity of brain tumors and to overexpression of many proteins compared to normal brain tissue. We demonstrate that non-neoplastic lesions are characterized by APT values significantly lower than low grade gliomas (LGGs). APTw imaging may lead to an increased accuracy in differentiating LGGs from non-neoplastic lesions in pediatric patients.

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Keywords