Abstract #2507

Combing APT-CEST imaging and NODDI for an early distinction between pure edema and infiltrative tumor in glioma at 7T

Yifan Yuan¹, Yang Yu², Jun Chang¹, Ying-Hua Chu³, Yi-Cheng Hsu³, He Wang⁴, Patrick Alexander Liebig⁵, Qi Yue¹, Liang Chen¹, and Ying Mao¹

¹Department of neurosurgery, Huashan Hospital Fudan University, Shanghai, China, ²Department of radiology, Huashan Hospital Fudan University, Shanghai, China, ³MR Collaboration, Siemens Healthineers Ltd, Shanghai, China, ⁴Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China, ⁵MR Collaboration, Siemens Healthineers Ltd, Erlangen, Germany

Synopsis

Keywords: Tumors, CEST & MT, NODDIGlioma grows infiltratively along fiber tracts, making it difficult to determine the tumor boundary. Extended resection may impair eloquent brain areas and cause functional disorders, while conservative resection often leaves tumor residues at the cutting edge, leading to early recurrence. This study uses APT-CEST imaging and NODDI to explore glioma's microstructural and metabolic characteristics. We trained a model from 100 biopsies to predict tumor presence in non-enhancing areas. This model shows potential for guiding precise glioma resection and radiotherapy.

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