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Abstract #2511

Deep learning-based DWI connectome analysis to improve the prediction of postoperative language improvement in pediatric epilepsy

Min-Hee Lee1,2, Nathan Sim3, Marie Papamarcos3, Masaki Sonoda4, Csaba Juhász1,2, Eishi Asano1,5, and Jeong-Won Jeong1,2
1Pediatrics, Wayne State University, Detroit, MI, United States, 2the Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI, United States, 3Medical Doctor Program, Wayne State University, Detroit, MI, United States, 4Neurosurgery, Yokohama City University, Yokohama, Japan, 5Neurology, Children's Hospital of Michigan, Detroit, MI, United States

Synopsis

Keywords: Neuro, Epilepsy, Prediction of postoperative language improvement in children with epilepsyWe present a novel deep learning-based tract classification to effectively remove false positive tract streamlines from preoperative DWI connectome data of children with medically intractable epilepsy. Compared to the prediction model without the presented classification where uncontrollable false positive tracts significantly limit the accurate prediction of postoperative language improvement using local efficiency values of key hub regions in the receptive and expressive language networks, the prediction model with the presented classification enhanced the accuracy of about 34% up to 100%/88% for the prediction of receptive/expressive language improvement, especially when the local efficiency values were combined with the clinical variables.

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Keywords