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Abstract #2514

Vascular territorial analysis of cerebral blood flow in pediatric Moyamoya to exclude arterial transit time bias

Rahel Heule1,2, Raimund Kottke3, and Ruth Tuura1,2
1Center for MR Research, University Children's Hospital, Zurich, Switzerland, 2Children's Research Center, University Children's Hospital, University of Zurich, Zurich, Switzerland, 3Department of Diagnostic Imaging, University Children’s Hospital, Zurich, Switzerland

Synopsis

Keywords: Neuro, Arterial spin labellingDelayed perfusion in patients with Moyamoya vasculopathy can lead to a bias in CBF quantification, especially for single-delay ASL acquisitions. In this work, we investigate the clinical utility of arterial transit time corrected CBF derived from a 7-delay prototype ASL sequence for assessment of hemodynamically mediated perfusion failure in pediatric Moyamoya patients. The multi-delay ASL acquisition proved successful in capturing the whole distribution of transit times in the investigated patient cohort and may thus be a valid contrast agent-free alternative to DSC-enhanced perfusion imaging.

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